AQP1 is not only a water channel

AQP1 Is Not Only a Water Channel: It Contributes to Cell Migration through Lin7/Beta-Catenin

AQPs are water channel proteins. In particular, AQP1 was demonstrated to be involved in cell migration. According to the model proposed by Verkman and collaborators, AQP drives water influx, facilitating lamellipodia extension and cell migration. Investigating the possible connection between AQP1 and cytoskeleton, our group showed that such a water channel through Lin7/beta-catenin affects the ...

Cloning and characterization of a zebrafish homologue of human AQP1: a bifunctional water and gas channel.

The mammalian aquaporins AQP1, AQP4, and AQP5 have been shown to function not only as water channels but also as gas channels. Zebrafish have two genes encoding an AQP1 homologue, aqp1a and aqp1b. In the present study, we cloned the cDNA that encodes the zebrafish protein Aqp1a from the 72-h postfertilization (hpf) embryo of Danio rerio, as well as from the swim bladder of the adult. The deduce...

Only Female Age, and Not Blood Type, Is Associated with Ovarian Reserve

Involvement of potassium channel in AQP1-mediated water and gas transport in erythrocytes

Elevated plasma cholesterol affects nearly 100 million Americans, a third of the US population, resulting in devastating health consequences and nearly one million deaths annually. Although the long-term effect of elevated plasma cholesterol is known for its accretion in arterial walls, little was understood of its immediate effects until recently (Jena and Lee, 2010). Cholesterol in blood plas...

Sex-dependent expression of water channel AQP1 along the rat nephron.

In the mammalian kidney, nonglycosylated and glycosylated forms of aquaporin protein 1 (AQP1) coexist in the luminal and basolateral plasma membranes of proximal tubule and descending thin limb. Factors that influence AQP1 expression in (patho)physiological conditions are poorly known. Thus far, only angiotensin II and hypertonicity were found to upregulate AQP1 expression in rat proximal tubul...